Mnemonic

Cranial Nerves III, IV and VI Bedside Test

A memory aid for testing the ocular motor nerves at the bedside.

Expansion

Eye movements, pupils, lids and diplopia together

Expansion

The test: with the head still, follow a target through an H pattern, then convergence, then the pupils. Ask about diplopia at each position and in which direction the images separate furthest.

Muscle supply, by the rhyme LR6 SO4, all the rest are 3:

  • VI (abducens): lateral rectus, so abduction
  • IV (trochlear): superior oblique, so depression in adduction and intorsion
  • III (oculomotor): all the rest, plus levator palpebrae superioris and the parasympathetic supply to the sphincter pupillae and ciliary muscle

The palsies

Nerve Eye position Diplopia Other
III Down and out Worse looking up and in Ptosis, dilated pupil if surgical
IV Slight elevation, extorsion Vertical, worse looking down and in, so on stairs Head tilt away from the lesion
VI Adducted, cannot abduct Horizontal, worse on looking to that side

The critical distinction in third nerve palsy

  • Surgical (compressive): the parasympathetic fibres run on the outside of the nerve, so they are compressed first. The pupil is dilated and unreactive, and there is often pain. Causes are posterior communicating artery aneurysm, uncal herniation and tumour. It is an emergency
  • Medical (ischaemic): the vasa vasorum supply the core, so the pupil is spared. Causes are diabetes, hypertension and giant cell arteritis

Internuclear ophthalmoplegia, from a medial longitudinal fasciculus lesion, gives failure of adduction with nystagmus in the abducting eye, and in a young patient suggests multiple sclerosis.