Mnemonic

Pressure Drop Across the Circulation

A memory aid for how pressure falls from aorta to vena cava.

Expansion

The greatest fall occurs across the arterioles

Expansion

Approximate mean pressures:

Site Pressure
Aorta 95 mmHg
Large arteries 90 mmHg
Arterioles 60 falling to 30 mmHg
Capillaries 30 falling to 15 mmHg
Venules 15 mmHg
Vena cava / right atrium 0 to 5 mmHg

The arterioles account for the largest single drop, which is why they are called the resistance vessels. Their smooth muscle is richly innervated and highly responsive, so they perform two jobs at once: setting systemic vascular resistance and therefore arterial pressure, and setting capillary hydrostatic pressure and therefore fluid exchange.

Pulsatility is also progressively damped, disappearing by the capillary level, so capillary flow is continuous. That damping is provided by the Windkessel elasticity of the great arteries.