Mnemonic

Third Nerve Palsy Triad

Mnemonic for the classic clinical triad of a complete CN III palsy.

Expansion

Down and out, lid's dropping, pupil's blown

Mnemonic

“Down and out, droopy and dilated”:

  • Down and out eye, from unopposed lateral rectus (VI) and superior oblique (IV)
  • Droopy, a complete ptosis from loss of levator palpebrae superioris
  • Dilated pupil, if the parasympathetic fibres are involved

The pupil is the whole diagnosis. The parasympathetic fibres run on the outside of the nerve, so:

  • Pupil involved (dilated) means compression: a posterior communicating artery aneurysm, uncal herniation or tumour. This is a surgical emergency
  • Pupil spared means ischaemia of the core through the vasa vasorum: diabetes, hypertension, giant cell arteritis

“Compression from the outside in, ischaemia from the inside out.”

Expansion

  • Down and out eye position - unopposed lateral rectus and superior oblique
  • Ptosis - loss of levator palpebrae superioris
  • Dilated unreactive pupil - loss of parasympathetic fibres to the sphincter pupillae